Selvakumar Edwardraja PhD
My Research Topics
Current projects
- Development of Synthetic Protein Biosensors for Nanotechnology platforms.
Past works (success stories...)
- Bioengineered multifunctional yeast nanofragments as universal nanoprobe
- Exploring performance parameters of artificial allosteric protein switches
- Engineering and exploiting synthetic allostery of NanoLuc luciferase
- Generation of Nanoyeast Single-Chain Variable Fragments as High-Avidity Biomaterials for Dengue Virus Detection
- Connecting Artificial Proteolytic and Electrochemical Signaling Systems with Caged Messenger Peptides
- Amplification-Free SARS-CoV-2 Detection
- Self-powered molecule release systems through reconfigurable Boolean logic gates
- Control of Allosteric Protein Electrochemical Switch Using Magnetic Signals
- Control of Allosteric Protein Electrochemical Switches
- Caged Activators for Synthetic Allosteric Protein Biosensors
- Protein Biosensors Based on Synthetic Switch Modules
- Engineering of 2nd Generation Antibody (Human Lipocalin2) Scaffold by Introducing Non-natural Amino Acids
- Rational Design of an Anticalin-Type Sugar-Binding Protein
- Design of dinuclear Mn-sites in artificial four-helix bundle proteins
- Sequence fingerprint for GFP-like fold
- Design of dinuclear manganese cofactors for bacterial reaction centers
- De novo designed metalloproteins and Copper coordination studies
- Targeted Delivery of Ubiquitin-Conjugated inhibitors into Cancer Cells
- Modeling of 3-Hydroxyisobutyrate Dehydrogenase
- Crystallization of mouse Mcl-1 with chemically stapled NOXA-B peptide inhibitors PDB ID: 4G35
- Copper-Free Sonogashira Cross-Coupling for Functionalization of Alkyne-Encoded Proteins in Aqueous Medium and in Bacterial Cells
- Enhancing the thermal stability of a single-chain Fv fragment by in vivo global fluorination of the proline residues
(wt-MscFv-model-kabat.pdb: PM0078682)
- In vivo Based N-Terminal Site Specific Modification with Bio-Orthogonal Reactive Group on scFv Proteins
- Redesigning of Fragment Antibodies for Bacterial Cytoplasmic Folding / Stability
- Comparative Structure Analysis of Fold Improvement Mutations on Cytoplasmic Stable vs Unstable scFv Proteins
(wt-MscFv-model-kabat.pdb: PM0076146)
(hu-MscFv-model-kabat.pdb: PM0076147)
- Genome-Wide Identification of Orthologous & Paralogous ALDH Proteins for 3-HP production
Subramanian Mohanraj et al., 2010
- Sequence Motif & Structure Analysis on ALDH Proteins
- Expression System Evaluation for Efficient Incorporation of Non-canonical Amino Acids into Proteins
Niraikulam Ayyadurai et al., 2009
- mRNA Secondary Structure Analysis on Domain Re-arrangements For Improved Folding/Production of scFv protein
Thesis works
Bioinformatics course - 2002-2003
- Prediction of Protein-Protein Interactions in Deinococcus radiodurans R1 strain using computational methods
- Identification of Genes Responsible
for Parasitic life:
Genome sequence comparison
Filarial parasite nematode vs Free-living nematode
for drug/vaccine targets identification
Masters course - 2000-2002
- Arboratics - Web Tool Development For Identification, Location and Documentation of Higher Plants Through Internet
Arboratics - 2002 (Preview)
Bachelors course - 1997-2000
- Studies On Cultivation Aspects Of Milky Mushroom (Calocybe indica P&C)
Research Interest
Protein Design & Engg.
Synthetic Biology
Bioinformatics
